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29-Dec-2017 10:21

However, many have chronic liver disease, which can range from mild to severe, including cirrhosis and liver cancer.Chronic liver disease in HCV-infected persons is usually insidious, progressing slowly without any signs or symptoms for several decades.In fact, HCV infection is often not recognized until asymptomatic persons are identified as HCV-positive when screened for blood donation or when elevated alanine aminotransferase (ALT, a liver enzyme) levels are detected during routine examinations.HCV testing is recommended for anyone at increased risk for HCV infection, including: A table on the interpretation of results of tests for hepatitis C Virus (HCV) infection and further actions is available at https://gov/hepatitis/HCV/PDFs/hcv_[PDF – 1 page].

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Older and former IDUs typically have a much higher prevalence (approximately 70%–90%) of HCV infection, reflecting the increased risk of continued injection drug use.This is because persons infected with HCV typically have an ineffective immune response due to changes in the virus during infection.For the same reason, no effective pre- or postexposure prophylaxis (i.e., immune globulin) is available. Chronic HCV infection is the leading indication for liver transplants in the United States.In those persons who do develop symptoms, the average time period from exposure to symptom onset is 4–12 weeks (range: 2–24 weeks).

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Most persons with chronic HCV infection are asymptomatic.CDC estimates that there were 19,659 deaths with HCV as an underlying or contributing cause of death in 2014.

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